Type your tag names separated by a space and hit enter


Fatigue is a topic covered in the 5-Minute Emergency Consult.

To view the entire topic, please or purchase a subscription.

Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:

Emergency Central

-- The first section of this topic is shown below --



  • A subjective state of overwhelming, sustained exhaustion and decreased capacity for physical and mental work that is not relieved by rest
  • Fatigue occurs with or without objective findings on physical exam.
  • Fatigue is a common complaint in people with and without systemic disease, which makes this complaint a challenge to practicing physicians.


  • The specific mechanisms of fatigue are unknown.
  • Hematologic:
    • Anemia
    • Leukemia
  • Endocrine:
    • Thyroid disorders
    • Adrenal insufficiency
    • Diabetes
    • Pregnancy
  • Malignancy:
    • Paraneoplastic syndromes
  • Psychiatric:
    • Chronic pain
    • Emotional distress
    • Depression
    • Eating disorders
    • Chemical dependency
    • Withdrawal syndromes
  • Sleep disorders:
    • Insomnia
    • Sleep apnea
  • Cardiac and pulmonary disorders
  • Infections acute and chronic
  • Rheumatic and autoimmune disorders
  • Nutritional deficiencies including electrolyte abnormalities
  • Physical inactivity and deconditioning
  • Medications
  • Chronic fatigue syndrome:
    • Symptom complex defined by the CDC
    • Severe chronic fatigue lasting >6 mo
    • Not explained by any medical or psychiatric diagnosis
    • Presence of 4 or more of the following 8 symptoms:
      • Headache
      • Arthralgias
      • Sleep disturbances
      • Lymphadenopathy
      • Exercise intolerance
      • Myalgias
      • Impaired memory/concentration
      • Sore throat

-- To view the remaining sections of this topic, please or purchase a subscription --


Rosen, Peter, et al., editors. "Fatigue." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307191/all/Fatigue.
Fatigue. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307191/all/Fatigue. Accessed April 20, 2019.
Fatigue. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307191/all/Fatigue
Fatigue [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 20]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307191/all/Fatigue.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Fatigue ID - 307191 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307191/all/Fatigue PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -