Pyloric Stenosis
To view the entire topic, please log in or purchase a subscription.
Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:
-- The first section of this topic is shown below --
Basics
Description
- Postnatal hypertrophy and hyperplasia of the circular smooth muscle cell layer causing a thickened pylorus and antrum leading to progressive gastric outlet obstruction
- Neuronal nitric oxide synthase (NOS-1) may be a genetic susceptibility locus
- Administration of erythromycin and azithromycin in infants during first 2 wk of life may increase risk of hypertrophic pyloric stenosis
- Jaundice due to transient glucuronyltransferase deficiency
- Adult: Caused by peptic ulcer disease
Etiology
- Most common cause of GI obstruction in infants; incidence 1/150 males, 1/750 females (average: 3/1,000 live births)
- Males affected 5× more commonly than females; firstborn most common
- Familial aggregation noted, 15%:
- Child of affected parent has 7% incidence
- Recurrence risk in subsequent male children is 10%; 2% in females
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Postnatal hypertrophy and hyperplasia of the circular smooth muscle cell layer causing a thickened pylorus and antrum leading to progressive gastric outlet obstruction
- Neuronal nitric oxide synthase (NOS-1) may be a genetic susceptibility locus
- Administration of erythromycin and azithromycin in infants during first 2 wk of life may increase risk of hypertrophic pyloric stenosis
- Jaundice due to transient glucuronyltransferase deficiency
- Adult: Caused by peptic ulcer disease
Etiology
- Most common cause of GI obstruction in infants; incidence 1/150 males, 1/750 females (average: 3/1,000 live births)
- Males affected 5× more commonly than females; firstborn most common
- Familial aggregation noted, 15%:
- Child of affected parent has 7% incidence
- Recurrence risk in subsequent male children is 10%; 2% in females
There's more to see -- the rest of this entry is available only to subscribers.