5-Minute Emergency Consult
Pyloric Stenosis
Pyloric Stenosis is a topic covered in the 5-Minute Emergency Consult.
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Basics
Description
Description
- Postnatal hypertrophy and hyperplasia of the circular smooth muscle cell layer causing a thickened pylorus and antrum leading to progressive gastric outlet obstruction
- Neuronal nitric oxide synthase (NOS-1) may be a genetic susceptibility locus.
- Administration of erythromycin in infants during 1st 2 wk of life may increase risk of hypertrophic pyloric stenosis.
- Jaundice due to transient glucuronyl transferase deficiency
- Adult: Caused by peptic ulcer disease
Etiology
Etiology
- Most common cause of GI obstruction in infants; incidence 1/150 males, 1/750 females (average: 3/1,000 live births)
- Males affected 5× more commonly than females; firstborn most common
- Familial, 15%:
- Child of affected parent has 7% incidence.
- Recurrence risk in subsequent male children is 10%; 2% in females.
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Basics
Description
Description
- Postnatal hypertrophy and hyperplasia of the circular smooth muscle cell layer causing a thickened pylorus and antrum leading to progressive gastric outlet obstruction
- Neuronal nitric oxide synthase (NOS-1) may be a genetic susceptibility locus.
- Administration of erythromycin in infants during 1st 2 wk of life may increase risk of hypertrophic pyloric stenosis.
- Jaundice due to transient glucuronyl transferase deficiency
- Adult: Caused by peptic ulcer disease
Etiology
Etiology
- Most common cause of GI obstruction in infants; incidence 1/150 males, 1/750 females (average: 3/1,000 live births)
- Males affected 5× more commonly than females; firstborn most common
- Familial, 15%:
- Child of affected parent has 7% incidence.
- Recurrence risk in subsequent male children is 10%; 2% in females.
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Citation
Rosen, Peter, et al., editors. "Pyloric Stenosis." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307156/all/Pyloric_Stenosis.
Pyloric Stenosis. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307156/all/Pyloric_Stenosis. Accessed January 24, 2020.
Pyloric Stenosis. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307156/all/Pyloric_Stenosis
Pyloric Stenosis [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2020 January 24]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307156/all/Pyloric_Stenosis.
* Article titles in AMA citation format should be in sentence-case
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