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Lead Poisoning

Lead Poisoning is a topic covered in the 5-Minute Emergency Consult.

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  • Lead has multiple mechanisms of toxicity:
    • Binds sulfhydryl groups and affects multiple enzymatic processes
    • Resembles Ca2+ thereby interfering with Ca2+-dependent processes, such as cell signaling
    • May have mutagenic potential and play a role in human carcinogenesis
  • Distribution:
    • Up to 99% of lead is bound to erythrocytes after initial absorption.
    • Ultimately redistributed into bone:
      • 95% of total body lead in adults
      • 70% of total body lead in children
    • High lead levels in the serum compromise the blood–brain barrier and result in lead entry into the CNS and neurotoxicity.
  • Often coexists with iron deficiency; this allows for increased lead absorption in the gut.
  • Impairs heme synthesis, leading to elevated free erythrocyte protoporphyrin (FEP); these complex with zinc, resulting in elevated zinc protoporphyrin (ZPP).
  • Levels correlate poorly with symptoms:
    • Associated with drops in intelligence quotient (IQ) and increase in violent behavior


  • Acute toxicity:
    • Most often due to inhalation of an environmental source or ingestion of substance containing lead
      • Pottery glaze
      • Certain folk remedies
      • Cosmetics
      • Jewelry
      • Weights
      • Home-distilled alcoholic beverages
      • Lead dust from ammunition and primer
  • Chronic toxicity:
    • Occupational exposures (usually via inhalation):
      • Battery manufacturing/recycling
      • Bridge painting
      • Construction workers
      • De-leading
      • Electronic waste recycling
      • Firing range instructors
      • Mining and smelting
      • Pottery workers
      • Welders
    • Home exposures (pediatric poisoning):
      • Lead-based paint inhalation/ingestion from toys and walls
      • Contaminated water from old pipes
      • Lead dust from the clothing of a parent exposed at work
      • Imported foods
      • Folk medicines

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Rosen, Peter, et al., editors. "Lead Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307146/all/Lead_Poisoning.
Lead Poisoning. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307146/all/Lead_Poisoning. Accessed April 23, 2019.
Lead Poisoning. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307146/all/Lead_Poisoning
Lead Poisoning [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 23]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307146/all/Lead_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Lead Poisoning ID - 307146 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307146/all/Lead_Poisoning PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -