Opiate Poisoning

Basics

Description

  • Bind to μ, κ, and δ opiate receptors in the CNS and peripheral nervous system (PNS)
  • Physical and psychological dependence occurs
  • Peak plasma levels:
    • PO: 1–2 hr
    • Intramuscular: 0.5–1 hr
    • Intravenous or intranasal: Seconds to minutes

Etiology

  • Overuse or abuse of oral prescription analgesics for moderate to severe pain
  • Street preparations of opioid analogs may contain adulterants:
    • Cocaine
    • Clenbuterol
    • Phencyclidine
    • Strychnine
    • Dextromethorphan
    • Quinine
    • Scopolamine

There's more to see -- the rest of this topic is available only to subscribers.