5-Minute Emergency Consult
Anticholinergic Poisoning
Anticholinergic Poisoning is a topic covered in the 5-Minute Emergency Consult.
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Basics
Description
Description
- Central and peripheral cholinergic blockade
- Depending on the drug involved, antagonism occurs at muscarinic (most common), nicotinic, or both receptors
- Onset of activity: 15–60 min after ingestion
- Duration of effect: 2–24 hr
Etiology
Etiology
- Many drugs contain anticholinergic properties:
- Mild at therapeutic doses
- Life threatening in overdose
- Anticholinergic substances:
- Antihistamines
- Belladonna alkaloids and synthetic congeners
- Antiparkinsonian drugs
- Cyclic antidepressants
- Antipsychotics (neuroleptics)
- Mydriatics
- Skeletal muscle relaxants (orphenadrine, cyclobenzaprine)
- Antispasmodics
- Mushrooms—Amanita muscaria, Amanita pantherina
- Plants—deadly nightshade, mandrake, henbane
- Jimson weed—smoked or ingested
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Basics
Description
Description
- Central and peripheral cholinergic blockade
- Depending on the drug involved, antagonism occurs at muscarinic (most common), nicotinic, or both receptors
- Onset of activity: 15–60 min after ingestion
- Duration of effect: 2–24 hr
Etiology
Etiology
- Many drugs contain anticholinergic properties:
- Mild at therapeutic doses
- Life threatening in overdose
- Anticholinergic substances:
- Antihistamines
- Belladonna alkaloids and synthetic congeners
- Antiparkinsonian drugs
- Cyclic antidepressants
- Antipsychotics (neuroleptics)
- Mydriatics
- Skeletal muscle relaxants (orphenadrine, cyclobenzaprine)
- Antispasmodics
- Mushrooms—Amanita muscaria, Amanita pantherina
- Plants—deadly nightshade, mandrake, henbane
- Jimson weed—smoked or ingested
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Citation
Schaider, Jeffrey J., et al., editors. "Anticholinergic Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning.
Anticholinergic Poisoning. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning. Accessed March 29, 2023.
Anticholinergic Poisoning. (2016). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (5th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning
Anticholinergic Poisoning [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2023 March 29]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning.
* Article titles in AMA citation format should be in sentence-case
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ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning
PB - Lippincott Williams & Wilkins
ET - 5
DB - Emergency Central
DP - Unbound Medicine
ER -
