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Anticholinergic Poisoning

Anticholinergic Poisoning is a topic covered in the 5-Minute Emergency Consult.

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  • Central and peripheral cholinergic blockade
  • Depending on the drug involved, antagonism occurs at muscarinic (most common), nicotinic, or both receptors.
  • Onset of activity: 15–30 min after ingestion
  • Duration of effect: 2–24 hr


  • Many drugs contain anticholinergic properties:
    • Mild at therapeutic doses
    • Life threatening in overdose
  • Anticholinergic substances:
    • Antihistamines
    • Belladonna alkaloids and synthetic congeners
    • Antiparkinsonian drugs
    • Cyclic antidepressants
    • Antipsychotics (neuroleptics)
    • Mydriatics
    • Skeletal muscle relaxants (orphenadrine, cyclobenzaprine)
    • Antispasmodics
    • Mushrooms—Amanita muscaria, Amanita pantherina
    • Plants—deadly nightshade, mandrake, henbane
    • Jimson weed—smoked or ingested

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* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Anticholinergic Poisoning ID - 307126 ED - Barkin,Adam Z, ED - Barkin,Roger M, ED - Hayden,Stephen R, ED - Rosen,Peter, ED - Schaider,Jeffrey J, ED - Shayne,Philip, ED - Wolfe,Richard E, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307126/all/Anticholinergic_Poisoning PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -