Reye Syndrome
Basics
Description
Description
- Reversible clinicopathologic syndrome of unknown etiology
- Primary mitochondrial injury
- Decreased enzyme activity:
- Krebs cycle
- Gluconeogenesis
- Urea biosynthesis
- Fatty infiltration:
- Liver:
- Hyperammonemia due to decreased conversion from ammonia to urea
- Hepatorenal syndrome may be the end result
- Rapid recovery of liver function in survivors
- Brain:
- Encephalopathy of unclear etiology
- Cytotoxic edema
- Deteriorating level of consciousness reflects increasing intracranial pressure (ICP)
- Herniation is the most common cause of death
- Normal recovery of neurologic function in survivors
- Skeletal and myocardial muscle
- Fatty infiltration and distorted mitochondria
- Liver:
- <10% of cases occur before the age of 1 yr:
- Average age is 7 yr
- Peak age is 4–11 yr
- Extremely rare in age >18 yr
- Regional differences:
- Highest incidence in the Midwestern states
- Lower incidence in the states of the Southeast and far West
- More common in whites than in blacks
- Peak incidence in winter and early spring
- Reye-like syndrome:
- Describes conditions resulting in defects in urea and fatty acid metabolism, toxicologic injury, and impaired gluconeogenesis
Etiology
Etiology
- Not known with certainty
- Multifactorial causes have been epidemiologically implicated:
- Antecedent viral syndrome
- Influenza A or B
- Varicella
- Diarrhea illness
- Genetic predisposition
- Exposure to salicylates
- Other undefined factors
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Citation
Schaider, Jeffrey J., et al., editors. "Reye Syndrome." 5-Minute Emergency Consult, 6th ed., Lippincott Williams & Wilkins, 2020. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307118/1.3/Reye_Syndrome.
Reye Syndrome. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307118/1.3/Reye_Syndrome. Accessed October 7, 2024.
Reye Syndrome. (2020). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (6th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307118/1.3/Reye_Syndrome
Reye Syndrome [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. [cited 2024 October 07]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307118/1.3/Reye_Syndrome.
* Article titles in AMA citation format should be in sentence-case
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T1 - Reye Syndrome
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ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
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PB - Lippincott Williams & Wilkins
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