Dysfunctional Uterine Bleeding

Dysfunctional Uterine Bleeding is a topic covered in the 5-Minute Emergency Consult.

To view the entire topic, please or purchase a subscription.

Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:

Emergency Central

-- The first section of this topic is shown below --



  • Abnormal uterine bleeding is an alteration in pattern or volume of normal menses
    • Typical blood loss during a normal menstrual cycle is 30–80 mL
    • Normal interval between menses 28 (+/− 7) days
  • 2 classifications
    • Dysfunctional uterine bleeding (DUB)
      • Hormonally related
      • Anovulatory and ovulatory categories
      • Not due to organic or iatrogenic causes
      • Diagnosis of exclusion
    • Organic uterine bleeding
      • Bleeding related to systemic illness or disease of the reproductive tract


  • Anovulatory (most common):
    • Unopposed estrogen stimulation of proliferative endometrium
    • Alteration of neuroendocrine function due to:
      • Polycystic ovarian syndrome (PCOS)
      • Very low calorie diets, rapid weight change, intense exercise, anorexia
      • Psychological stress
      • Obesity
      • Drugs
      • Hypothyroidism
      • Primary hypothalamic dysfunction
  • Ovulatory:
    • Inadequate uterine PGF2α
      • Increased uterine contractility
    • Excessive uterine prostacycline
      • Diminishes platelet function and increases uterine vasodilation

Pediatric Considerations
Anovulatory bleeding common in adolescence owing to immaturity of the hypothalamic–pituitary–ovarian axis

-- To view the remaining sections of this topic, please or purchase a subscription --