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Hypernatremia is a topic covered in the 5-Minute Emergency Consult.

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Hypernatremia definition: Sodium >145 mEq/L:
  • Mild hypernatremia: Serum sodium 146–155 mEq/L
  • Severe hypernatremia: Serum sodium >155 mEq/L


Divided into 3 categories

Hypovolemic Hypernatremia
  • Most common
  • Loss or deficiency of water and sodium with water losses being greater than sodium losses
  • Examples:
    • Renal failure
    • Medications (e.g., diuretics, lactulose)
    • Osmotic diuresis (mannitol, glucosuria, high protein feedings)
    • Insensible losses (burns, sweating)
    • Respiratory loss
    • Defective thirst mechanism
    • Lack of access to water
    • Diarrhea/vomiting
    • Intubated patients

Isovolemic Hypernatremia
  • Water deficiency without sodium loss; free water loss
  • Examples:
    • Fever
    • Hypothalamic diabetes insipidus (DI):
      • Head trauma
      • Tumor
      • Congenital
      • Infection (TB, syphilis, mycoses, toxoplasmosis, encephalitis)
      • Granulomatous disease (sarcoid, Wegner)
      • Cerebrovascular accident
      • Aneurysm
    • Nephrogenic DI:
      • Congenital
      • Drugs (lithium, amphotericin B, foscarnet, demeclocycline)
      • Obstructive uropathy
      • Chronic tubulointerstitial disease (sickle cell nephropathy, multiple myeloma, amyloidosis, sarcoidosis, systemic lupus erythematosus, polycystic kidney)
      • Electrolyte disorders (hypercalcemia, potassium depletion)

Hypervolemic Hypernatremia
  • Gain of water and sodium, with sodium gain greater than water gain.
  • Examples:
    • Iatrogenic—most common cause:
      • Sodium bicarbonate administration
      • NaCl tablets
      • Hypertonic parenteral hyperaliment
      • Hypertonic IV fluid (IVF)
      • Hypertonic dialysis
    • Hypertonic medicine preparations such as ticarcillin and carbenicillin
    • Cushing disease
    • Adrenal hyperplasia
    • Primary aldosteronism
    • Sea water drownings

Pediatric Considerations
  • More prone to iatrogenic causes
  • More likely to die or to have permanent neurologic sequelae
  • Morbidity ranges from 25% to 50%.
  • May present with high-pitched cry, lethargy, irritability, muscle weakness
  • Poor breast feeding and inappropriate formula preparations are a potential cause in neonates
  • If hypernatremia is due to DKA, follow pediatric DKA protocols for fluid resuscitation
  • DDAVP dose for 3 mo–12 yr is 5–30 μg/day intranasally
    • Consider NG hydration

Geriatric Considerations
  • Most commonly affected group due to impaired renal concentrating ability and reduced thirst mechanism
  • Consider neglect if underlying etiology is dehydration alone

Pregnancy Considerations
  • May encounter transient DI of pregnancy
  • Vasopressin and desmopressin are category B drugs in pregnancy
  • Hydration status much more difficult to evaluate accurately by exam

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Rosen, Peter, et al., editors. "Hypernatremia." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307047/all/Hypernatremia.
Hypernatremia. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307047/all/Hypernatremia. Accessed April 26, 2019.
Hypernatremia. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307047/all/Hypernatremia
Hypernatremia [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 26]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307047/all/Hypernatremia.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hypernatremia ID - 307047 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307047/all/Hypernatremia PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -