Anaphylaxis
Basics
Description
Description
- An acute, widely distributed form of shock that occurs within minutes of exposure to antigen in a sensitized individual
- The overall rate of anaphylaxis appears to be increasing, especially in children
- An overall incidence rate of about 50 per 100,000 person-years is estimated from current data:
- Fortunately, case fatality rates are low for patients who make it to the ED (0.1–0.3%)
- Involves release of bioactive molecules such as histamine, leukotrienes, and prostaglandins from inflammatory cells:
- Mediator release results in increased vascular permeability, vasodilation, smooth-muscle contractions, and increased epithelial secretion
- Physiologically, this is manifested in a decrease in total peripheral resistance, venous return, and cardiac output, as well as intravascular volume depletion
Etiology
Etiology
- IgE mediated:
- Antibiotics, particularly penicillin family
- Venoms, esp bee and wasp
- Latex
- Vaccines
- Foodstuffs (shellfish, soybeans, peanuts, tree nuts, wheat, milk, eggs)
- Monoclonal antibody therapeutics
- Non-IgE mediated:
- Iodine contrast media
- Opiates
- Vancomycin:
- Usually can be prevented by reducing rate of infusion
- Seminal fluid
- Exercise
Pediatric Considerations
In children, foods are an important trigger for IgE-mediated anaphylaxis:
- The most common foods to cause anaphylactic events are peanuts, tree nuts, fish, shellfish, milk, and egg, but any food can produce a reaction
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Citation
Schaider, Jeffrey J., et al., editors. "Anaphylaxis." 5-Minute Emergency Consult, 6th ed., Lippincott Williams & Wilkins, 2020. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307031/1.3/Anaphylaxis.
Anaphylaxis. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307031/1.3/Anaphylaxis. Accessed October 15, 2024.
Anaphylaxis. (2020). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (6th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307031/1.3/Anaphylaxis
Anaphylaxis [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. [cited 2024 October 15]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307031/1.3/Anaphylaxis.
* Article titles in AMA citation format should be in sentence-case
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T1 - Anaphylaxis
ID - 307031
ED - Barkin,Adam Z,
ED - Shayne,Philip,
ED - Rosen,Peter,
ED - Schaider,Jeffrey J,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307031/1.3/Anaphylaxis
PB - Lippincott Williams & Wilkins
ET - 6
DB - Emergency Central
DP - Unbound Medicine
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