Peptic Ulcer
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Basics
Description
- Produced by breakdown in gastric or duodenal mucosal defenses
- Imbalance exists between production of acid and ability of mucosa to prevent damage
Etiology
- Helicobacter pylori:
- Gram-negative spiral bacteria that live in mucous layer
- Responsible for 90–95% of duodenal ulcers and 80% of gastric ulcers
- Increases antral gastrin production and decreases mucosal integrity
- NSAIDs:
- Interfere with prostaglandin synthesis
- Lead to break in mucosa
- Aspirin
- Cigarette smoking
- Alcohol
- Severe physiologic stress
- Hypersecretory states (uncommon)
- Ischemic causes
- Genetics (>20% have family history)
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Produced by breakdown in gastric or duodenal mucosal defenses
- Imbalance exists between production of acid and ability of mucosa to prevent damage
Etiology
- Helicobacter pylori:
- Gram-negative spiral bacteria that live in mucous layer
- Responsible for 90–95% of duodenal ulcers and 80% of gastric ulcers
- Increases antral gastrin production and decreases mucosal integrity
- NSAIDs:
- Interfere with prostaglandin synthesis
- Lead to break in mucosa
- Aspirin
- Cigarette smoking
- Alcohol
- Severe physiologic stress
- Hypersecretory states (uncommon)
- Ischemic causes
- Genetics (>20% have family history)
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