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Peptic Ulcer

Peptic Ulcer is a topic covered in the 5-Minute Emergency Consult.

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  • Produced by breakdown in gastric or duodenal mucosal defenses
  • Imbalance exists between production of acid and ability of mucosa to prevent damage.


  • Helicobacter pylori:
    • Gram-negative spiral bacteria that live in mucous layer
    • Responsible for 90–95% of duodenal ulcers and 80% of gastric ulcers
    • Increases antral gastrin production and decreases mucosal integrity
  • NSAIDs:
    • Interfere with prostaglandin synthesis
    • Lead to break in mucosa
  • Aspirin
  • Cigarette smoking
  • Alcohol
  • Severe physiologic stress
  • Hypersecretory states (uncommon)
  • Genetics (>20% have family history)

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Rosen, Peter, et al., editors. "Peptic Ulcer." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307017/all/Peptic_Ulcer.
Peptic Ulcer. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307017/all/Peptic_Ulcer. Accessed April 24, 2019.
Peptic Ulcer. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307017/all/Peptic_Ulcer
Peptic Ulcer [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 24]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307017/all/Peptic_Ulcer.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Peptic Ulcer ID - 307017 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307017/all/Peptic_Ulcer PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -