Hypopituitarism

Etiology

Mass lesions

  • Pituitary adenoma (prolactinoma, nonfunctioning, growth hormone-secreting)
  • Granuloma
  • Brain tumor (eg, craniopharyngioma, meningioma, germinoma, glioma, chondrosarcoma, chordoma of the clivus)
  • Rathke’s cleft cyst
  • Aneurysm
  • Pituitary apoplexy (hemorrhage in pituitary tumor)
  • Metastatic carcinoma
Without mass lesion
  • Idiopathic
  • Trauma
  • Cranial irradiation
  • Hemochromatosis
  • Sarcoidosis
  • Surgery
  • Encephalitis
  • Autoimmune
  • Stroke
  • Status post-coronary artery bypass graft
  • Postpartum pituitary necrosis (Sheehan’s syndrome)
  • Langerhans cell histiocytosis
  • Eclampsia-preeclampsia
  • Sickle cell disease
  • African trypanosomiasis

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