As a selective beta-3 adrenergic agonist, it relaxes the detrusor smooth muscles, which increases bladder capacity during storage phase of bladder fill-void cycle.
Distribution: Extensively distributed to extravascular tissues.
Metabolism and Excretion: Some metabolism in liver via CYP3A4 isoenzyme. Primarily excreted in feces (59%; 54% as unchanged drug), with 20% excreted in urine (19% as unchanged drug).
Monitor voiding pattern and intake and output, and assess abdomen for bladder distention prior to and periodically during therapy, particularly in patients at ↑ risk of bladder outlet obstruction. If urinary retention occurs, discontinue vibegron.
Geri: Assess older adults for anticholinergic effects (sedation and weakness).
PO Administer once daily without regard to food. Swallow tablets whole with a glass of water. Tablets also may be crushed, mixed with a tablespoon (15 mL) of applesauce, and taken immediately with a glass of water.
Instruct patient to take vibegron as directed. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Advise patient to notify health care professional if urinary retention (cannot empty bladder) occurs or if constipation persists. Discuss methods of preventing constipation, such as ↑ dietary bulk, fluid intake, and mobility.
Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: Advise women of reproductive potential to notify health care professional if pregnancy is planned or suspected or if breastfeeding.