Symptomatic relief of non-infectious diarrhea in HIV-infected patients currently receiving antiretroviral therapy.
A natural product derived from Croton lechleri, a species of flowering plant.
Inhibits cyclic adenosine monophosphate (cAMP)-stimulated cystic fibrosis transmembrane conductance regulator (CTFR) chloride ion channels and the calcium-activated chloride channels on luminal membranes of enterocytes. Blocks chloride secretion and water loss by inhibiting chloride channels on the membranes of enterocytes.
Decreased incidence and severity of diarrhea.
Absorption: Minimal absorption following oral administration.
Metabolism and Excretion: Unknown.
Use Cautiously in:
Infectious causes of diarrhea (evaluate and treat prior to use);
OB: Use during pregnancy only if clearly needed;
Lactation: Breast feeding should be avoided by HIV-infected patients;
Pedi: Safe and effective use in children <18 yr has not been established.
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