Nonsteroidal Anti-Inflammatory Poisoning
Basics
Basics
Basics
Description
Description
- Inhibit cyclooxygenase (COX), thereby blocking the conversion of arachidonic acid to prostaglandin
- Typically morbidity is low when an NSAID is ingested
- Most literature on nonselective NSAID toxicity involves ibuprofen exposure likely due to its OTC availability
- Fatalities have been reported with large ingestions
- Greater potential for toxicity with underlying CHF or renal failure:
- NSAIDs cause sodium and water retention and decrease renal blood flow
- Little overdose experience with the COX-2 inhibitors (celecoxib); treatment should be the same as for the traditional NSAIDs
Etiology
Etiology
- Nonsteroidal medications are available by prescription and over-the-counter
- NSAIDs include:
- Diclofenac
- Diflunisal
- Etodolac
- Fenoprofen
- Ibuprofen
- Indomethacin
- Ketoprofen
- Ketorolac
- Meclofenamate
- Mefenamic acid
- Meloxicam
- Nabumetone
- Naproxen
- Oxaprozin
- Piroxicam
- Sulindac
- Tolmetin
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