Multiple Sclerosis
Basics
Basics
Basics
Description
Description
Description
- Pathophysiology: Recurrent episodes of CNS demyelination leading to varied clinical presentations based on lesion locations
- Patterns:
- Relapsing-remitting MS: ≥2 episodes lasting ≥24 hr, separated by ≥1 mo
- Primary progressive MS: Continuous progression over ≥6 mo
- Secondary progressive MS: Initial relapses followed by continuous progression over ≥6 mo
- Stable MS: No progression without treatment over ≥18 mo
Etiology
Etiology
Etiology
- Nature: Chronic demyelinating CNS disease
- Cause: Presumed T cell–mediated autoimmune disease with possible viral triggers
- Epidemiology: Higher prevalence in individuals of northern European descent and increases with distance from the equator
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