Reperfusion Therapy, Cerebral
Basics
Basics
Basics
Description
Description
- An ischemic cerebrovascular accident (CVA), or stroke, is sudden interruption of regional cerebral blood supply
- Cerebral reperfusion therapy involves:
- Intravenous (IV) thrombolysis with IV recombinant tissue-plasminogen activator (tPA), alteplase
- Endovascular mechanical embolectomy with a stent retriever
Etiology
Etiology
- Thrombotic CVA: Thrombosis from atherothrombotic lesion, hypercoagulable state, sludging
- Embolic CVA: Acute obstruction by an embolus from elsewhere, such as cardiac mural thrombus, aortic plaque, prosthetic cardiac valve
- Other occlusive events: Dissection, vasospasm
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