Carbamazepine Poisoning

Basics

Description

  • Therapeutic uses of carbamazepine:
    • Anticonvulsant
    • Treatment of chronic pain
    • Migraine prophylaxis
    • Mood stabilizer
  • Mechanism:
    • Anticholinergic
    • Similarities to phenytoin and tricyclic antidepressants (TCAs)
    • Sodium channel blocker
    • Decreases synaptic transmission

Etiology

Toxicity may occur from:
  • Suicide attempt
  • Accidental ingestion
  • Supratherapeutic dosing
  • Drug–drug interaction

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